With infertility populations in the developed world rapidly aging, treatment of diminished ovarian
reserve (DOR) assumes increasing clinical importance. Dehydroepiandrosterone (DHEA) has been reported to
improve pregnancy chances with DOR, and is now utilized by approximately one third of all IVF centers worldwide.
Increasing DHEA utilization and publication of a first prospectively randomized trial now warrants a systematic review.
Methods: PubMed, Cochrane and Ovid Medline were searched between 1995 and 2010 under the following
strategy: [ and ]. Bibliographies of relevant publications were further explored for additional relevant citations. Since only one randomized study has been published, publications, independent of evidence levels and quality assessment, were reviewed.
Results: Current best available evidence suggests that DHEA improves ovarian function, increases pregnancy
chances and, by reducing aneuploidy, lowers miscarriage rates. DHEA over time also appears to objectively
improve ovarian reserve. Recent animal data support androgens in promoting preantral follicle growth and
reduction in follicle atresia.
Discussion: Improvement of oocyte/embryo quality with DHEA supplementation potentially suggests a new
concept of ovarian aging, where ovarian environments, but not oocytes themselves, age. DHEA may, thus,
represent a first agent beneficially affecting aging ovarian environments. Others can be expected to follow.
Reference : Gleicher and Barad Reproductive Biology and Endocrinology 2011, 9:67
Norbert Gleicher1,2* and David H Barad1,3