Treatment for pain management has become increasingly challenging, as tolerance, dependence, risk of debilitating side effects and interactions between different drug combinations prove to be a constant struggle for prescribers, pharmacists and patients to consider. Coupling this, with the fact that most chronic pain patients suffer from multiple co-morbid diseases, further complicates effective therapy. For years, the gold standard in pain management involved systemic or parenteral therapy. In recent years, commercial transdermal patches and gels became available, offering an alternative route of administration for patients. The clinical research that emerged supporting these alternative dosage forms opened the door for prescribers and pharmacists to use their pharmacology knowledge to offer topical and transdermal pain creams, customized to the individual needs of the patient.